Domino’s Hand Tossed Pepperoni Pizza (Medium 12-inch): Price, Calories and Nutrition (2026)
The pepperoni pizza is the anchor of every pizza menu in America, and Domino’s Hand Tossed Pepperoni is the one most people picture when they think of delivery pizza: a medium 12-inch round on hand tossed crust, pepperoni over mozzarella and Domino’s robust tomato sauce, cut into 8 slices. What you pay depends heavily on how you order: in 2026 a medium 12-inch Hand Tossed Pepperoni carries 220 calories per slice and a price starting from $7.99 through the carryout deal, with the regular menu price at $9.99. Here is the current price, the calorie count, and the full nutrition breakdown.
Prices vary by location because Domino’s stores are franchise-operated, and delivery runs higher once fees and tip are added. The from $7.99 price is the carryout deal for any 1-topping pizza. The regular menu price for a medium 1-topping pizza is $9.99. The Mix & Match deal covers 2-topping pizzas, so a 1-topping pepperoni does not qualify.
Last updated: June 11, 2026
Table of contents
- What is in the Hand Tossed Pepperoni Pizza
- Hand Tossed Pepperoni Pizza nutrition facts
- Hand Tossed Pepperoni Pizza ingredients and customization
- Allergens
- Hand Tossed Pepperoni Pizza vs Handmade Pan Pepperoni
- Getting the best value on the Hand Tossed Pepperoni Pizza
- Frequently asked questions
What is in the Hand Tossed Pepperoni Pizza
The build is simple, which is why it works. A medium 12-inch hand tossed crust forms the base, spread with robust tomato sauce, topped with mozzarella, and finished with a generous layer of pepperoni slices that cup and crisp at the edges in the oven. The hand tossed crust is the classic: stretched dough with a soft, chewy center and a slightly puffy rim.
At 220 calories per slice, this is one of the lightest standard pizzas on the menu: 9 grams of fat from the pepperoni and cheese, 25 grams of carbs from the crust, a respectable 8 grams of protein, and 520 mg of sodium per slice.
The pepperoni itself is the star. Domino’s uses a pork and beef pepperoni that is spicier than the average chain version, with fennel and pepper notes that come through clearly. Because it sits on top of the cheese, the slices render in the oven heat and develop crispy edges with little cupped centers. That contrast, chewy crust, stretchy cheese, crisp pepperoni, is what makes a great pepperoni pizza.
The medium 12-inch is the sweet spot: it portions cleanly for two people sharing with a side, or one hungry person across a day. For most households, this is the default order, and it is priced like one.
Hand Tossed Pepperoni Pizza nutrition facts
Full nutrition breakdown for one slice (1/8 of a medium 12-inch pizza), based on Domino’s official US nutrition data. Standard build, hand tossed crust.
| Nutrient | Amount per slice |
|---|---|
| Calories | 220 |
| Total fat | 9g |
| Total carbohydrates | 25g |
| Protein | 8g |
| Sodium | 520mg |
The 220 calorie figure is the headline. Against a 2000 calorie daily guideline, one slice is 11 percent, and a two-slice serving of 440 calories works comfortably as a full meal. Three slices land at 660 calories and deliver 24 grams of protein, which keeps the meal from being an empty-carb experience.
The honest framing: a full medium eaten solo is 1760 calories. But among indulgent fast food dinners, this is one of the more portionable choices. Two satisfying slices and you are done, which is harder to say about a basket of wings. Sodium is the watch item past three slices: four slices push past 2000 mg.
Hand Tossed Pepperoni Pizza ingredients and customization
The standard ingredient list is hand tossed pizza dough (wheat flour, yeast, water, salt), robust tomato sauce (tomato puree, spices), mozzarella cheese (milk, cheese culture, salt), and pepperoni (pork, beef, spices, paprika).
Customization starts with the crust: thin for a lighter bite, or Handmade Pan for a thick, buttery base (medium 12-inch only, extra charge may apply). Adding a second topping changes the deal math: a 2-topping medium qualifies for the $6.99 Mix & Match deal with two or more qualifying items, while the 1-topping pepperoni does not.
The practical move: order the medium 1-topping pepperoni as a carryout for $7.99. Want a second topping at the best price? Order two qualifying 2-topping pizzas under Mix & Match at $6.99 each. Light cheese, extra sauce, and garlic seasoning on the rim cost nothing at most stores.
Allergens
Contains wheat and gluten (crust), milk (mozzarella), and possibly soy from processing aids. The pepperoni contains pork and beef. Stores prepare egg, fish, tree nuts, peanuts, and sesame on shared equipment, so cross-contact is possible. Check Domino’s current allergen information if you have a serious allergy.
Hand Tossed Pepperoni Pizza vs Handmade Pan Pepperoni
The crust question, settled with numbers. Hand Tossed Pepperoni (medium 12-inch): 220 calories per slice, 9g fat, 25g carbs, 8g protein, 520mg sodium, from $7.99. Handmade Pan Pepperoni (medium 12-inch): 310 calories per slice, 16g fat, 29g carbs, 11g protein, 550mg sodium, from $11.99.
Hand tossed wins on calories, fat, and price by wide margins: 90 calories lighter per slice, nearly half the fat, and about four dollars cheaper. Pan wins on richness and satisfaction per slice. The thick, buttery crust baked fresh to order makes each slice a heavier, more filling event, and it brings 11 grams of protein per slice versus 8.
Pick hand tossed for the classic experience, for two or three slices without a calorie blowout, and when price matters. Pick Handmade Pan for indulgence, at about $2 more than the hand tossed equivalent. Weeknight default: hand tossed. Friday night treat: pan.
Getting the best value on the Hand Tossed Pepperoni Pizza
- At from $7.99, the carryout deal for any 1-topping pizza is the best price. Pick it up and skip delivery fees.
- Menu price is $9.99, so check the site or app for deals before ever paying full price.
- Mix & Match at $6.99 each needs two or more qualifying 2-topping items, so a 1-topping pepperoni does not qualify. Add a topping and pair it to unlock it.
- 8 slices at 220 calories each. A 2-slice serving is 440 calories: portion first, then box the rest.
- Deals rotate. Check the Domino’s deals page before every order, since the best price is rarely the menu price.
Frequently asked questions
How much is a medium Domino’s pepperoni pizza in 2026?
From $7.99 through the carryout deal for any 1-topping pizza. The regular menu price is $9.99. Prices vary by location, and delivery costs more with fees and tip.
How many calories are in one slice?
One slice of a medium 12-inch Hand Tossed Pepperoni has 220 calories, with 9g of fat, 25g of carbs, 8g of protein, and 520mg of sodium, per Domino’s official 2026 nutrition data.
Is the $7.99 price carryout only?
Yes. The $7.99 deal covers any 1-topping pizza ordered for carryout. Delivery orders run higher once delivery fees and tip are added.
Does the pepperoni pizza qualify for Mix & Match?
No. Mix & Match is $6.99 each for two or more qualifying 2-topping items. Add a second topping and pair it with another qualifying item to unlock the deal.
How many calories are in a whole medium pepperoni pizza?
A medium is 8 slices at 220 calories each, so the whole pizza is 1760 calories. A 2-slice serving of 440 calories makes a reasonable meal against a 2000 calorie daily guideline.
Hand tossed or pan: which crust should I pick?
Hand tossed is lighter at 220 calories a slice, cheaper from $7.99, and the classic experience. Handmade Pan is richer at 310 calories a slice and starts from $11.99. Pick hand tossed for weeknights and pan for an indulgent weekend treat.
ManuBite Team. We track fast food prices and nutrition across the USA so you always know what your meal really costs, in dollars and in calories.
Want more Domino’s menu favourites? Check our ExtravaganZZa Feast guide, our MeatZZa Feast guide and our Brooklyn Style Pepperoni guide for prices, calories and nutrition facts.
One Comment